Wisconsin Sleep Cohort Study

Publications

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2023

The genetic etiology of periodic limb movement in sleep. Edelson JL, Schneider LD, Amar D, Brink-Kjaer A, Cederberg KL, Kutalik Z, Hagen EW, Peppard PE, Tempaku PF, Tufik S, Evans DS, Stone K, Tranah G, Cade B, Redline S, Haba-Rubio J, Heinzer R, Marques-Vidal P, Vollenweider P, Winkelmann J, Zou J, Mignot E.Sleep. 2023 Apr 12;46(4):zsac121. doi: 10.1093/sleep/zsac121.

Metabolic health disparities driven by financial stress: Behavioural adaptation or modification? Kuo WC, Bratzke LC, Hagen EW, Hale L, Brown RL, Barnet JH, Peppard PE.Stress Health. 2023 Aug;39(3):614-626. doi: 10.1002/smi.3210. Epub 2022 Dec 1.

Association between stressful life events and non-optimal lipid levels among women with hyperlipidaemia. Kuo WC, Ersig AL, Johnson HM, Brown RL, Oakley LD, Hagen EW, Barnet JH, Peppard PE.Eur J Cardiovasc Nurs. 2023 Mar 1;22(2):210-219. doi: 10.1093/eurjcn/zvac032.

Cardiorespiratory Fitness Attenuates the Deleterious Effects of Sleep Apnea on Cerebral Structure and Perfusion in the Wisconsin Sleep Cohort Study. Edmunds KJ, Driscoll I, Hagen EW, Barnet JH, Ravelo LA, Plante DT, Gaitán JM, Lose SR, Motovylyak A, Bendlin BB, Okonkwo OC, Peppard PE.J Alzheimers Dis. 2023 Aug 1. doi: 10.3233/JAD-220910. Online ahead of print.

OSA-Onset: An algorithm for predicting the age of OSA onset. Olaithe M, Hagen EW, Barnet JH, Eastwood PR, Bucks RS. Sleep Med. 2023 Aug;108:100-104. doi: 10.1016/j.sleep.2023.05.018. Epub 2023 Jun 8.

2022

Age estimation from sleep studies using deep learning predicts life expectancy.Brink-Kjaer A, Leary EB, Sun H, Westover MB, Stone KL, Peppard PE, Lane NE, Cawthon PM, Redline S, Jennum P, Sorensen HBD, Mignot E.NPJ Digit Med. 2022 Jul 22;5(1):103. doi: 10.1038/s41746-022-00630-9

Foldager J, Peppard PE, Hagen EW, Stone KL, Evans DS, Tranah GJ, Sørensen H, Jennum P, Mignot E, Schneider LD. Genetic risk for subjective reports of insomnia associates only weakly with polygraphic measures of insomnia in 2,770 adults. J Clin Sleep Med. 2022 Jan 1;18(1):21-29. doi: 10.5664/jcsm.9468. PMID: 34170227; PMCID: PMC8807892.

2021

Liu Y, Palta M, Barnet JH, Roberts MT, Hagen EW, Peppard PE, Reither EN. Habitual sleep, sleep duration differential, and weight change among adults: Findings from the Wisconsin Sleep Cohort Study. Sleep Health. 2021 Oct 19:651. doi: 10.1016/j.sleh.2021.09.005. Epub ahead of print. PMID: 34686460.

Reither EN, Barnet JH, Palta M, Liu Y, Hagen EW, Peppard PE. Polysomnographic indicators of restorative sleep and body mass trajectories in the Wisconsin Sleep Cohort Study. Sleep. 2021 Aug 13;44(8):zsab031. doi: 10.1093/sleep/zsab031. PMID: 34145899; PMCID: PMC8361330.

Wallace ML, Coleman TS, Mentch LK, Buysse DJ, Graves JL, Hagen EW, Hall MH, Stone KL, Redline S, Peppard PE. Physiological sleep measures predict time to 15-year mortality in community adults: Application of a novel machine learning framework. J Sleep Res. 2021 May 15:e13386. doi: 10.1111/jsr.13386. Epub ahead of print. PMID: 33991144.

Moon C, Hagen EW, Johnson HM, Brown RL, Peppard PE. Longitudinal sleep characteristics and hypertension status: results from the Wisconsin Sleep Cohort Study. J Hypertens. 2021 Apr 1;39(4):683-691. doi: 10.1097/HJH.0000000000002692. PMID: 33186322.

Kuo WC, Oakley LD, Brown RL, Hagen EW, Barnet JH, Peppard PE, Bratzke LC. Gender Differences in the Relationship Between Financial Stress and Metabolic Abnormalities. Nurs Res. 2021 Mar-Apr 01;70(2):123-131. doi: 10.1097/NNR.0000000000000489. PMID: 33630535; PMCID: PMC8106736.

2020

Leary EB, Watson KT, Ancoli-Israel S, Redline S, Yaffe K, Ravelo LA, Peppard PE, Zou J, Goodman SN, Mignot E, Stone KL. Association of Rapid Eye Movement Sleep With Mortality in Middle-aged and Older Adults. JAMA Neurol. 2020 Jul 6;77(10):1–12. doi: 10.1001/jamaneurol.2020.2108. Epub ahead of print. PMID: 32628261.

Brink-Kjaer A, Olesen AN, Peppard PE, Stone KL, Jennum P, Mignot E, Sorensen HBD. Automatic detection of cortical arousals in sleep and their contribution to daytime sleepiness. Clin Neurophysiol. 2020 Jun;131(6):1187-1203. doi: 10.1016/j.clinph.2020.02.027. Epub 2020 Apr 2. PMID: 32299002.

Carvelli L, Olesen AN, Brink-Kjær A, Leary EB, Peppard PE, Mignot E, Sørensen HBD, Jennum P. Design of a deep learning model for automatic scoring of periodic and non-periodic leg movements during sleep validated against multiple human experts. Sleep Med. 2020 May;69:109-119. doi: 10.1016/j.sleep.2019.12.032. Epub 2020 Jan 23. PMID: 32062037.

Lyu B, Hagen EW, Ravelo LA, Peppard PE. Blood pressure dipping and sleep quality in the Wisconsin Sleep Cohort. J Hypertens. 2020 Mar;38(3):448-455. doi: 10.1097/HJH.0000000000002283. PMID: 31714339.

Plante DT, Hagen EW, Ravelo LA, Peppard PE. Impaired neurobehavioral alertness quantified by the psychomotor vigilance task is associated with depression in the Wisconsin Sleep Cohort study. Sleep Med. 2020 Mar;67:66-70. doi: 10.1016/j.sleep.2019.11.1248. Epub 2019 Dec 4. PMID: 31918119.

Mesas AE, Peppard PE, Hale L, Friedman EM, Nieto FJ, Hagen EW. Individuals’ perceptions of social support from family and friends are associated with lower risk of sleep complaints and short sleep duration. Sleep Health. 2020 Feb;6(1):110-116. doi: 10.1016/j.sleh.2019.08.013. Epub 2019 Nov 16. PMID: 31740375.

2019

Harden CM, Peppard PE, Palta M, Barnet JH, Hale L, Nieto FJ, Hagen EW. One-year changes in self-reported napping behaviors across the retirement transition. Sleep Health. 2019 Dec;5(6):639-646. doi: 10.1016/j.sleh.2019.08.005. Epub 2019 Nov 11. PMID: 31727591.

Mallinson DC, Kamenetsky ME, Hagen EW, Peppard PE. Subjective sleep measurement: comparing sleep diary to questionnaire. Nat Sci Sleep. 2019 Sep 11;11:197-206. doi: 10.2147/NSS.S217867. PMID: 31686932; PMCID: PMC6752706.

Sankari A, Ravelo LA, Maresh S, Aljundi N, Alsabri B, Fawaz S, Hamdon M, Al-Kubaisi G, Hagen E, Badr MS, Peppard P. Longitudinal effect of nocturnal R-R intervals changes on cardiovascular outcome in a community-based cohort. BMJ Open. 2019 Jul 17;9(7):e030559. doi: 10.1136/bmjopen-2019-030559. PMID: 31315880; PMCID: PMC6661586.

Devita M, Peppard PE, Mesas AE, Mondini S, Rusconi ML, Barnet JH, Hagen EW. Associations Between the Apnea-Hypopnea Index During REM and NREM Sleep and Cognitive Functioning in a Cohort of Middle-Aged Adults. J Clin Sleep Med. 2019 Jul 15;15(7):965-971. doi: 10.5664/jcsm.7872. PMID: 31383233; PMCID: PMC6622515.

Canales MT, Hagen EW, Barnet JH, Peppard PE, Derose SF. Response to “Does renal function decline slower in those with sleep apnea?”. Sleep. 2019 Jun 11;42(6):zsz084. doi: 10.1093/sleep/zsz084. PMID: 31184757.

Lacourse K, Delfrate J, Beaudry J, Peppard P, Warby SC. A sleep spindle detection algorithm that emulates human expert spindle scoring. J Neurosci Methods. 2019 Mar 15;316:3-11. doi: 10.1016/j.jneumeth.2018.08.014. Epub 2018 Aug 11. PMID: 30107208; PMCID: PMC6415669.

2018

Stephansen JB, Olesen AN, Olsen M, Ambati A, Leary EB, Moore HE, Carrillo O, Lin L, Han F, Yan H, Sun YL, Dauvilliers Y, Scholz S, Barateau L, Hogl B, Stefani A, Hong SC, Kim TW, Pizza F, Plazzi G, Vandi S, Antelmi E, Perrin D, Kuna ST, Schweitzer PK, Kushida C, Peppard PE, Sorensen HBD, Jennum P, Mignot E. Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy. Nat Commun. 2018 Dec 6;9(1):5229. doi: 10.1038/s41467-018-07229-3. PMID: 30523329; PMCID: PMC6283836.

Mesas AE, Hagen EW, Peppard PE. The bidirectional association between physical activity and sleep in middle-aged and older adults: a prospective study based on polysomnography. Sleep. 2018 Sep 1;41(9):zsy114. doi: 10.1093/sleep/zsy114. PMID: 29860437; PMCID: PMC6132624.

Peppard PE, Hagen EW. Reply to Holley and Phillips: The Next 25 Years of Obstructive Sleep Apnea Epidemiology-Don’t Keep Repeating Past Mistakes. Am J Respir Crit Care Med. 2018 Aug 1;198(3):410-411. doi: 10.1164/rccm.201803-0467LE. PMID: 29596753.

Olesen AN, Jennum P, Peppard P, Mignot E, Sorensen HBD. Deep residual networks for automatic sleep stage classification of raw polysomnographic waveforms. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8513080. PMID: 30440296.

Chen H, Cade BE, Gleason KJ, Bjonnes AC, Stilp AM, Sofer T, Conomos MP, Ancoli-Israel S, Arens R, Azarbarzin A, Bell GI, Below JE, Chun S, Evans DS, Ewert R, Frazier-Wood AC, Gharib SA, Haba-Rubio J, Hagen EW, Heinzer R, Hillman DR, Johnson WC, Kutalik Z, Lane JM, Larkin EK, Lee SK, Liang J, Loredo JS, Mukherjee S, Palmer LJ, Papanicolaou GJ, Penzel T, Peppard PE, Post WS, Ramos AR, Rice K, Rotter JI, Sands SA, Shah NA, Shin C, Stone KL, Stubbe B, Sul JH, Tafti M, Taylor KD, Teumer A, Thornton TA, Tranah GJ, Wang C, Wang H, Warby SC, Wellman DA, Zee PC, Hanis CL, Laurie CC, Gottlieb DJ, Patel SR, Zhu X, Sunyaev SR, Saxena R, Lin X, Redline S. Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol. 2018 Mar;58(3):391-401. doi: 10.1165/rcmb.2017-0237OC. PMID: 29077507; PMCID: PMC5854957.

Olsen M, Schneider LD, Cheung J, Peppard PE, Jennum PJ, Mignot E, Sorensen HBD. Automatic, electrocardiographic-based detection of autonomic arousals and their association with cortical arousals, leg movements, and respiratory events in sleep. Sleep. 2018 Mar 1;41(3):zsy006. doi: 10.1093/sleep/zsy006. PMID: 29329416; PMCID: PMC5914410.

Peppard PE, Hagen EW. The Last 25 Years of Obstructive Sleep Apnea Epidemiology-and the Next 25? Am J Respir Crit Care Med. 2018 Feb 1;197(3):310-312. doi: 10.1164/rccm.201708-1614PP. PMID: 29035088.

Ruoff C, Pizza F, Trotti LM, Sonka K, Vandi S, Cheung J, Pinto S, Einen M, Simakajornboon N, Han F, Peppard P, Nevsimalova S, Plazzi G, Rye D, Mignot E. The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study. J Clin Sleep Med. 2018 Jan 15;14(1):65-74. doi: 10.5664/jcsm.6882. PMID: 29198301; PMCID: PMC5734895.

Canales MT, Hagen EW, Barnet JH, Peppard PE, Derose SF. Sleep Apnea and Kidney Function Trajectory: Results From a 20-Year Longitudinal Study of Healthy Middle-Aged Adults. Sleep. 2018 Jan 1;41(1):zsx181. doi: 10.1093/sleep/zsx181. PMID: 29112764; PMCID: PMC5806556.

2017

Owens RL, Gold KA, Gozal D, Peppard PE, Jun JC, Dannenberg AJ, Lippman SM, Malhotra A; UCSD Sleep and Cancer Symposium Group. Sleep and Breathing … and Cancer? Cancer Prev Res (Phila). 2016 Nov;9(11):821-827. doi: 10.1158/1940-6207.CAPR-16-0092. Epub 2016 Sep 7. Erratum in: Cancer Prev Res (Phila). 2017 Jan;10 (1):98. PMID: 27604751; PMCID: PMC5353979.

Koch H, Schneider LD, Finn LA, Leary EB, Peppard PE, Hagen E, Sorensen HBD, Jennum P, Mignot E. Breathing Disturbances Without Hypoxia Are Associated With Objective Sleepiness in Sleep Apnea. Sleep. 2017 Nov 1;40(11):zsx152. doi: 10.1093/sleep/zsx152. PMID: 29029253; PMCID: PMC6251661.

Hale L, Singer L, Barnet JH, Peppard PE, Hagen EW. Associations Between Midlife Insomnia Symptoms and Earlier Retirement. Sleep Health. 2017 Jun;3(3):170-177. doi: 10.1016/j.sleh.2017.03.003. Epub 2017 Apr 1. PMID: 28526254.

Olsen AV, Stephansen J, Leary E, Peppard PE, Sheungshul H, Jennum PJ, Sorensen H, Mignot E. Diagnostic value of sleep stage dissociation as visualized on a 2-dimensional sleep state space in human narcolepsy. J Neurosci Methods. 2017 Apr 15;282:9-19. doi: 10.1016/j.jneumeth.2017.02.004. Epub 2017 Feb 20. PMID: 28219726.

Mirer AG, Young T, Palta M, Benca RM, Rasmuson A, Peppard PE. Sleep-disordered breathing and the menopausal transition among participants in the Sleep in Midlife Women Study. Menopause. 2017 Feb;24(2):157-162. doi: 10.1097/GME.0000000000000744. PMID: 27760083; PMCID: PMC5266663.

Plante DT, Finn LA, Hagen EW, Mignot E, Peppard PE. Longitudinal associations of hypersomnolence and depression in the Wisconsin Sleep Cohort Study. J Affect Disord. 2017 Jan 1;207:197-202. doi: 10.1016/j.jad.2016.08.039. Epub 2016 Oct 3. PMID: 27723544; PMCID: PMC5107142.

2016

Tattersall MC, Barnet JH, Korcarz CE, Hagen EW, Peppard PE, Stein JH. Late-Onset Asthma Predicts Cardiovascular Disease Events: The Wisconsin Sleep Cohort. J Am Heart Assoc. 2016 Aug 24;5(9):e003448. doi: 10.1161/JAHA.116.003448. PMID: 27559071; PMCID: PMC5079014.

Korcarz CE, Peppard PE, Young TB, Chapman CB, Hla KM, Barnet JH, Hagen E, Stein JH. Effects of Obstructive Sleep Apnea and Obesity on Cardiac Remodeling: The Wisconsin Sleep Cohort Study. Sleep. 2016 Jun 1;39(6):1187-95. doi: 10.5665/sleep.5828. PMID: 27091525; PMCID: PMC4863205.

Stein JH, Stern R, Barnet JH, Korcarz CE, Hagen EW, Young T, Peppard PE. Relationships between sleep apnea, cardiovascular disease risk factors, and aortic pulse wave velocity over 18 years: the Wisconsin Sleep Cohort. Sleep Breath. 2016 May;20(2):813-7. doi: 10.1007/s11325-015-1181-3. Epub 2015 Apr 26. PMID: 25913148; PMCID: PMC4621266.

Plante DT, Finn LA, Hagen EW, Mignot E, Peppard PE. Subjective and Objective Measures of Hypersomnolence Demonstrate Divergent Associations with Depression among Participants in the Wisconsin Sleep Cohort Study. J Clin Sleep Med. 2016 Apr 15;12(4):571-8. doi: 10.5664/jcsm.5694. PMID: 26888592; PMCID: PMC4795285.

Hagen EW, Barnet JH, Hale L, Peppard PE. Changes in Sleep Duration and Sleep Timing Associated with Retirement Transitions. Sleep. 2016 Mar 1;39(3):665-73. doi: 10.5665/sleep.5548. PMID: 26564125; PMCID: PMC4763359.

2015

Gunnarsson SI, Peppard PE, Korcarz CE, Barnet JH, Hagen EW, Hla KM, Palta M, Young T, Stein JH. Minimal nocturnal oxygen saturation predicts future subclinical carotid atherosclerosis: the Wisconsin sleep cohort. J Sleep Res. 2015 Dec;24(6):680-6. doi: 10.1111/jsr.12321. Epub 2015 Jun 22. PMID: 26096939; PMCID: PMC4626295.

Christensen JA, Munk EG, Peppard PE, Young T, Mignot E, Sorensen HB, Jennum P. The diagnostic value of power spectra analysis of the sleep electroencephalography in narcoleptic patients. Sleep Med. 2015 Dec;16(12):1516-27. doi: 10.1016/j.sleep.2015.09.005. Epub 2015 Sep 15. PMID: 26611950.

Christensen JA, Carrillo O, Leary EB, Peppard PE, Young T, Sorensen HB, Jennum P, Mignot E. Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy. Sleep Med. 2015 Dec;16(12):1558-66. doi: 10.1016/j.sleep.2015.06.007. Epub 2015 Jul 7. PMID: 26299470.

Mokhlesi B, Hagen EW, Finn LA, Hla KM, Carter JR, Peppard PE. Obstructive sleep apnoea during REM sleep and incident non-dipping of nocturnal blood pressure: a longitudinal analysis of the Wisconsin Sleep Cohort. Thorax. 2015 Nov;70(11):1062-9. doi: 10.1136/thoraxjnl-2015-207231. Epub 2015 Aug 25. PMID: 26307037.

Li J, Moore H 4th, Lin L, Young T, Finn L, Peppard PE, Mignot E. Association of low ferritin with PLM in the Wisconsin Sleep Cohort. Sleep Med. 2015 Nov;16(11):1413-1418. doi: 10.1016/j.sleep.2015.05.015. Epub 2015 Jun 18. PMID: 26498245.

Mirer AG, Peppard PE, Palta M, Benca RM, Rasmuson A, Young T. Menopausal hormone therapy and sleep-disordered breathing: evidence for a healthy user bias. Ann Epidemiol. 2015 Oct;25(10):779-84.e1. doi: 10.1016/j.annepidem.2015.07.004. Epub 2015 Aug 6. PMID: 26358364; PMCID: PMC5645789.

Gottlieb DJ, Hek K, Chen TH, Watson NF, Eiriksdottir G, Byrne EM, Cornelis M, Warby SC, Bandinelli S, Cherkas L, Evans DS, Grabe HJ, Lahti J, Li M, Lehtimäki T, Lumley T, Marciante KD, Pérusse L, Psaty BM, Robbins J, Tranah GJ, Vink JM, Wilk JB, Stafford JM, Bellis C, Biffar R, Bouchard C, Cade B, Curhan GC, Eriksson JG, Ewert R, Ferrucci L, Fülöp T, Gehrman PR, Goodloe R, Harris TB, Heath AC, Hernandez D, Hofman A, Hottenga JJ, Hunter DJ, Jensen MK, Johnson AD, Kähönen M, Kao L, Kraft P, Larkin EK, Lauderdale DS, Luik AI, Medici M, Montgomery GW, Palotie A, Patel SR, Pistis G, Porcu E, Quaye L, Raitakari O, Redline S, Rimm EB, Rotter JI, Smith AV, Spector TD, Teumer A, Uitterlinden AG, Vohl MC, Widen E, Willemsen G, Young T, Zhang X, Liu Y, Blangero J, Boomsma DI, Gudnason V, Hu F, Mangino M, Martin NG, O’Connor GT, Stone KL, Tanaka T, Viikari J, Gharib SA, Punjabi NM, Räikkönen K, Völzke H, Mignot E, Tiemeier H. Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Version 2. Mol Psychiatry. 2015 Oct;20(10):1232-9. doi: 10.1038/mp.2014.133. Epub 2014 Dec 2. PMID: 25469926; PMCID: PMC4430294.

Wendt SL, Welinder P, Sorensen HB, Peppard PE, Jennum P, Perona P, Mignot E, Warby SC. Inter-expert and intra-expert reliability in sleep spindle scoring. Clin Neurophysiol. 2015 Aug;126(8):1548-56. doi: 10.1016/j.clinph.2014.10.158. Epub 2014 Nov 10. PMID: 25434753; PMCID: PMC4426257.

Teodorescu M, Barnet JH, Hagen EW, Palta M, Young TB, Peppard PE. Association between asthma and risk of developing obstructive sleep apnea. JAMA. 2015 Jan 13;313(2):156-64. doi: 10.1001/jama.2014.17822. Erratum in: JAMA. 2015 Jul 7;314(1):86. PMID: 25585327; PMCID: PMC4334115.

Hla KM, Young T, Hagen EW, Stein JH, Finn LA, Nieto FJ, Peppard PE. Coronary heart disease incidence in sleep disordered breathing: the Wisconsin Sleep Cohort Study. Sleep. 2015 May 1;38(5):677-84. doi: 10.5665/sleep.4654. PMID: 25515104; PMCID: PMC4402672.

2014

Moore H 4th, Leary E, Lee SY, Carrillo O, Stubbs R, Peppard P, Young T, Widrow B, Mignot E. Design and validation of a periodic leg movement detector. PLoS One. 2014 Dec 9;9(12):e114565. doi: 10.1371/journal.pone.0114565. Erratum in: PLoS One. 2015;10(9):e0138205. PMID: 25489744; PMCID: PMC4260847.

Mokhlesi B, Finn LA, Hagen EW, Young T, Hla KM, Van Cauter E, Peppard PE. Obstructive sleep apnea during REM sleep and hypertension. Results of the Wisconsin Sleep Cohort. Am J Respir Crit Care Med. 2014 Nov 15;190(10):1158-67. doi: 10.1164/rccm.201406-1136OC. PMID: 25295854; PMCID: PMC4299639.

Gunnarsson SI, Peppard PE, Korcarz CE, Barnet JH, Aeschlimann SE, Hagen EW, Young T, Hla KM, Stein JH. Obstructive sleep apnea is associated with future subclinical carotid artery disease: thirteen-year follow-up from the Wisconsin sleep cohort. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2338-42. doi: 10.1161/ATVBAHA.114.303965. Epub 2014 Sep 4. PMID: 25189572; PMCID: PMC4259877.

Korcarz CE, Stein JH, Peppard PE, Young TB, Barnet JH, Nieto FJ. Combined effects of sleep disordered breathing and metabolic syndrome on endothelial function: the Wisconsin Sleep Cohort study. Sleep. 2014 Oct 1;37(10):1707-13. doi: 10.5665/sleep.4086. PMID: 25197813; PMCID: PMC4173927.

Moore H 4th, Winkelmann J, Lin L, Finn L, Peppard P, Mignot E. Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD. Sleep. 2014 Sep 1;37(9):1535-42. doi: 10.5665/sleep.4006. PMID: 25142570; PMCID: PMC4153066.

Goldbart A, Peppard P, Finn L, Ruoff CM, Barnet J, Young T, Mignot E. Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort. Sleep. 2014 Jun 1;37(6):1043-51. doi: 10.5665/sleep.3758. PMID: 24882899; PMCID: PMC4015378.

Warby SC, Wendt SL, Welinder P, Munk EG, Carrillo O, Sorensen HB, Jennum P, Peppard PE, Perona P, Mignot E. Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods. Version 2. Nat Methods. 2014 Apr;11(4):385-92. doi: 10.1038/nmeth.2855. Epub 2014 Feb 23. PMID: 24562424; PMCID: PMC3972193.

2013

Andlauer O, Moore H, Jouhier L, Drake C, Peppard PE, Han F, Hong SC, Poli F, Plazzi G, O’Hara R, Haffen E, Roth T, Young T, Mignot E. Nocturnal rapid eye movement sleep latency for identifying patients with narcolepsy/hypocretin deficiency. JAMA Neurol. 2013 Jul;70(7):891-902. doi: 10.1001/jamaneurol.2013.1589. Erratum in: JAMA Neurol. 2013 Oct;70(10):1332. PMID: 23649748; PMCID: PMC4170796.

Nikodemova M, Finn L, Mignot E, Salzieder N, Peppard PE. Association of sleep disordered breathing and cognitive deficit in APOE ε4 carriers. Sleep. 2013 Jun 1;36(6):873-80. doi: 10.5665/sleep.2714. PMID: 23729930; PMCID: PMC3649829.

Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013 May 1;177(9):1006-14. doi: 10.1093/aje/kws342. Epub 2013 Apr 14. PMID: 23589584; PMCID: PMC3639722.

Hagen EW, Mirer AG, Palta M, Peppard PE. The sleep-time cost of parenting: sleep duration and sleepiness among employed parents in the Wisconsin Sleep Cohort Study. Am J Epidemiol. 2013 Mar 1;177(5):394-401. doi: 10.1093/aje/kws246. Epub 2013 Feb 1. PMID: 23378502; PMCID: PMC3626047.

2012

Morrell MJ, Finn L, McMillan A, Peppard PE. The impact of ageing and sex on the association between sleepiness and sleep disordered breathing. Eur Respir J. 2012 Aug;40(2):386-93. doi: 10.1183/09031936.00177411. Epub 2012 Jan 12. PMID: 22241742; PMCID: PMC3608395.

Nieto FJ, Peppard PE, Young T, Finn L, Hla KM, Farré R. Sleep-disordered breathing and cancer mortality: results from the Wisconsin Sleep Cohort Study. Am J Respir Crit Care Med. 2012 Jul 15;186(2):190-4. doi: 10.1164/rccm.201201-0130OC. Epub 2012 May 20. PMID: 22610391; PMCID: PMC3406081.

Awad KM, Malhotra A, Barnet JH, Quan SF, Peppard PE. Exercise is associated with a reduced incidence of sleep-disordered breathing. Am J Med. 2012 May;125(5):485-90. doi: 10.1016/j.amjmed.2011.11.025. PMID: 22482846; PMCID: PMC3339801.

2011

Vardeny O, Peppard PE, Finn LA, Faraco JH, Mignot E, Hla KM. β2 adrenergic receptor polymorphisms and nocturnal blood pressure dipping status in the Wisconsin Sleep Cohort Study. J Am Soc Hypertens. 2011 Mar-Apr;5(2):114-22. doi: 10.1016/j.jash.2011.01.005. Erratum in: J Am Soc Hypertens. 2011 May-Jun;5(3):193. PMID: 21414566; PMCID: PMC3071556.

2010

Morgan BJ, Reichmuth KJ, Peppard PE, Finn L, Barczi SR, Young T, Nieto FJ. Effects of sleep-disordered breathing on cerebrovascular regulation: A population-based study. Am J Respir Crit Care Med. 2010 Dec 1;182(11):1445-52. doi: 10.1164/rccm.201002-0313OC. Epub 2010 Jul 16. PMID: 20639438; PMCID: PMC3029932.

Korcarz CE, Gepner AD, Peppard PE, Young TB, Stein JH. The effects of sleep-disordered breathing on arterial stiffness are modulated by age. Sleep. 2010 Aug;33(8):1081-5. doi: 10.1093/sleep/33.8.1081. PMID: 20815190; PMCID: PMC2910537.

Szklo-Coxe M, Young T, Peppard PE, Finn LA, Benca RM. Prospective associations of insomnia markers and symptoms with depression. Am J Epidemiol. 2010 Mar 15;171(6):709-20. doi: 10.1093/aje/kwp454. Epub 2010 Feb 18. PMID: 20167581; PMCID: PMC2842222.

Arzt M, Young T, Peppard PE, Finn L, Ryan CM, Bayley M, Bradley TD. Dissociation of obstructive sleep apnea from hypersomnolence and obesity in patients with stroke. Stroke. 2010 Mar;41(3):e129-34. doi: 10.1161/STROKEAHA.109.566463. Epub 2010 Jan 14. PMID: 20075361; PMCID: PMC4230450.

2009

Peppard PE, Ward NR, Morrell MJ. The impact of obesity on oxygen desaturation during sleep-disordered breathing. Am J Respir Crit Care Med. 2009 Oct 15;180(8):788-93. doi: 10.1164/rccm.200905-0773OC. Epub 2009 Jul 30. PMID: 19644043; PMCID: PMC2778152.

Young T, Palta M, Dempsey J, Peppard PE, Nieto FJ, Hla KM. Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study. WMJ. 2009 Aug;108(5):246-9. PMID: 19743755; PMCID: PMC2858234.

Bautista LE, Stein JH, Morgan BJ, Stanton N, Young T, Nieto FJ. Association of blood and hair mercury with blood pressure and vascular reactivity. WMJ. 2009 Aug;108(5):250-2. PMID: 19743756; PMCID: PMC4593490.

Hallmayer J, Faraco J, Lin L, Hesselson S, Winkelmann J, Kawashima M, Mayer G, Plazzi G, Nevsimalova S, Bourgin P, Hong SC, Honda Y, Honda M, Högl B, Longstreth WT Jr, Montplaisir J, Kemlink D, Einen M, Chen J, Musone SL, Akana M, Miyagawa T, Duan J, Desautels A, Erhardt C, Hesla PE, Poli F, Frauscher B, Jeong JH, Lee SP, Ton TG, Kvale M, Kolesar L, Dobrovolná M, Nepom GT, Salomon D, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Young T, Peppard P, Tokunaga K, Kwok PY, Risch N, Mignot E. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet. 2009 Jun;41(6):708-11. doi: 10.1038/ng.372. Epub 2009 May 3. Erratum in: Nat Genet. 2009 Jul;41(7):859. Hong, Sheng Seung-Chul [corrected to Hong, Seung-Chul]. PMID: 19412176; PMCID: PMC2803042.

Young T. Rationale, design and findings from the Wisconsin Sleep Cohort Study: Toward understanding the total societal burden of sleep disordered breathing. Sleep Med Clin. 2009 Mar 1;4(1):37-46. doi: 10.1016/j.jsmc.2008.11.003. PMID: 20161300; PMCID: PMC2699290.

2008

Young T, Finn L, Peppard PE, Szklo-Coxe M, Austin D, Nieto FJ, Stubbs R, Hla KM. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep. 2008 Aug;31(8):1071-8. PMID: 18714778; PMCID: PMC2542952.

2007

Kim H, Dinges DF, Young T. Sleep-disordered breathing and psychomotor vigilance in a community-based sample. Sleep. 2007 Oct;30(10):1309-16. doi: 10.1093/sleep/30.10.1309. PMID: 17969464; PMCID: PMC2266275.

Szklo-Coxe M, Young T, Finn L, Mignot E. Depression: relationships to sleep paralysis and other sleep disturbances in a community sample. J Sleep Res. 2007 Sep;16(3):297-312. doi: 10.1111/j.1365-2869.2007.00600.x. PMID: 17716279; PMCID: PMC2800990.

Taheri S, Austin D, Lin L, Nieto FJ, Young T, Mignot E. Correlates of serum C-reactive protein (CRP)–no association with sleep duration or sleep disordered breathing. Sleep. 2007 Aug;30(8):991-6. doi: 10.1093/sleep/30.8.991. PMID: 17702268; PMCID: PMC1978379.

2006

Peppard PE, Szklo-Coxe M, Hla KM, Young T. Longitudinal association of sleep-related breathing disorder and depression. Arch Intern Med. 2006 Sep 18;166(16):1709-15. doi: 10.1001/archinte.166.16.1709. PMID: 16983048.

Arzt M, Young T, Finn L, Skatrud JB, Ryan CM, Newton GE, Mak S, Parker JD, Floras JS, Bradley TD. Sleepiness and sleep in patients with both systolic heart failure and obstructive sleep apnea. Arch Intern Med. 2006 Sep 18;166(16):1716-22. doi: 10.1001/archinte.166.16.1716. PMID: 16983049.

Mignot E, Lin L, Finn L, Lopes C, Pluff K, Sundstrom ML, Young T. Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults. Brain. 2006 Jun;129(Pt 6):1609-23. doi: 10.1093/brain/awl079. Epub 2006 Apr 5. PMID: 16597649.

2005

Arzt M, Young T, Finn L, Skatrud JB, Bradley TD. Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med. 2005 Dec 1;172(11):1447-51. doi: 10.1164/rccm.200505-702OC. Epub 2005 Sep 1. PMID: 16141444; PMCID: PMC2718439.

Young T, Peppard PE, Taheri S. Excess weight and sleep-disordered breathing. J Appl Physiol (1985). 2005 Oct;99(4):1592-9. doi: 10.1152/japplphysiol.00587.2005. PMID: 16160020.

Reichmuth KJ, Austin D, Skatrud JB, Young T. Association of sleep apnea and type II diabetes: a population-based study. Am J Respir Crit Care Med. 2005;172(12):1590-1595. doi:10.1164/rccm.200504-637OC

Kim H, Young T. Subjective daytime sleepiness: dimensions and correlates in the general population. Sleep. 2005 May;28(5):625-34. doi: 10.1093/sleep/28.5.625. PMID: 16171277.

Young T, Peppard PE. Clinical presentation of OSAS: gender does matter. Sleep. 2005 Mar;28(3):293-5. PMID: 16173646.

2004

Lin L, Finn L, Zhang J, Young T, Mignot E. Angiotensin-converting enzyme, sleep-disordered breathing, and hypertension. Am J Respir Crit Care Med. 2004 Dec 15;170(12):1349-53. doi: 10.1164/rccm.200405-616OC. Epub 2004 Sep 24. PMID: 15447944.

Taheri S, Lin L, Austin D, Young T, Mignot E. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004 Dec;1(3):e62. doi: 10.1371/journal.pmed.0010062. Epub 2004 Dec 7. PMID: 15602591; PMCID: PMC535701.

Peppard PE, Young T. Exercise and sleep-disordered breathing: an association independent of body habitus. Sleep. 2004 May 1;27(3):480-4. doi: 10.1093/sleep/27.3.480. PMID: 15164902.

Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA. 2004 Apr 28;291(16):2013-6. doi: 10.1001/jama.291.16.2013. PMID: 15113821.

2003

Young T, Rabago D, Zgierska A, Austin D, Laurel F. Objective and subjective sleep quality in premenopausal, perimenopausal, and postmenopausal women in the Wisconsin Sleep Cohort Study. Sleep. 2003 Sep;26(6):667-72. doi: 10.1093/sleep/26.6.667. PMID: 14572118.

Punjabi NM, Bandeen-Roche K, Young T. Predictors of objective sleep tendency in the general population. Sleep. 2003 Sep;26(6):678-83. doi: 10.1093/sleep/26.6.678. PMID: 14572120.

Young T, Finn L, Austin D, Peterson A. Menopausal status and sleep-disordered breathing in the Wisconsin Sleep Cohort Study. Am J Respir Crit Care Med. 2003 May 1;167(9):1181-5. doi: 10.1164/rccm.200209-1055OC. Epub 2003 Feb 13. PMID: 12615621.

2002

Pedrazzoli M, Ling L, Young TB, Finn L, Tufik S, Mignot E. Effect of the prion 129 polymorphism on nocturnal sleep and insomnia complaints: a population-based study. J Sleep Res. 2002 Dec;11(4):357-8. doi: 10.1046/j.1365-2869.2002.00318.x. PMID: 12464104.

Hla KM, Skatrud JB, Finn L, Palta M, Young T. The effect of correction of sleep-disordered breathing on BP in untreated hypertension. Chest. 2002 Oct;122(4):1125-32. doi: 10.1378/chest.122.4.1125. PMID: 12377832.

Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002 May 1;165(9):1217-39. doi: 10.1164/rccm.2109080. PMID: 11991871.

2001

Young T, Finn L, Palta M. Chronic nasal congestion at night is a risk factor for snoring in a population-based cohort study. Arch Intern Med. 2001 Jun 25;161(12):1514-9. doi: 10.1001/archinte.161.12.1514. PMID: 11427099.

Kadotani H, Kadotani T, Young T, Peppard PE, Finn L, Colrain IM, Murphy GM Jr, Mignot E. Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults. JAMA. 2001 Jun 13;285(22):2888-90. doi: 10.1001/jama.285.22.2888. PMID: 11401610.

2000

Peppard PE, Young T, Palta M, Dempsey J, Skatrud J. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000 Dec 20;284(23):3015-21. doi: 10.1001/jama.284.23.3015. PMID: 11122588.

Morrell MJ, Finn L, Kim H, Peppard PE, Badr MS, Young T. Sleep fragmentation, awake blood pressure, and sleep-disordered breathing in a population-based study. Am J Respir Crit Care Med. 2000 Dec;162(6):2091-6. doi: 10.1164/ajrccm.162.6.9904008. PMID: 11112120.

Phillips B, Young T, Finn L, Asher K, Hening WA, Purvis C. Epidemiology of restless legs symptoms in adults. Arch Intern Med. 2000 Jul 24;160(14):2137-41. doi: 10.1001/archinte.160.14.2137. PMID: 10904456.

Young T, Peppard P. Sleep-disordered breathing and cardiovascular disease: epidemiologic evidence for a relationship. Sleep. 2000 Jun 15;23 Suppl 4:S122-6. PMID: 10893084.

Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med. 2000 May 11;342(19):1378-84. doi: 10.1056/NEJM200005113421901. PMID: 10805822.

Pedrazzoli M, Ling L, Finn L, Kubin L, Young T, Katzenberg D, Mignot E. A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults. Sleep Res Online. 2000;3(2):73-6. PMID: 11382904.

1999

Katzenberg D, Young T, Lin L, Finn L, Mignot E. A human period gene (HPER1) polymorphism is not associated with diurnal preference in normal adults. Psychiatr Genet. 1999 Jun;9(2):107-9. doi: 10.1097/00041444-199906000-00011. PMID: 10412192.

Mignot E, Young T, Lin L, Finn L. Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602. Sleep. 1999 May 1;22(3):347-52. PMID: 10341385.

1998

Finn L, Young T, Palta M, Fryback DG. Sleep-disordered breathing and self-reported general health status in the Wisconsin Sleep Cohort Study. Sleep. 1998 Nov 1;21(7):701-6. PMID: 11286346.

Morgan BJ, Dempsey JA, Pegelow DF, Jacques A, Finn L, Palta M, Skatrud JB, Young TB. Blood pressure perturbations caused by subclinical sleep-disordered breathing. Sleep. 1998 Nov 1;21(7):737-46. doi: 10.1093/sleep/21.7.737. PMID: 11286350.

Katzenberg D, Young T, Finn L, Lin L, King DP, Takahashi JS, Mignot E. A CLOCK polymorphism associated with human diurnal preference. Sleep. 1998 Sep 15;21(6):569-76. doi: 10.1093/sleep/21.6.569. PMID: 9779516.

Mignot E, Young T, Lin L, Finn L, Palta M. Reduction of REM sleep latency associated with HLA-DQB1*0602 in normal adults. Lancet. 1998 Mar 7;351(9104):727. doi: 10.1016/S0140-6736(05)78496-8. PMID: 9504524.

1997

Kim HC, Young T, Matthews CG, Weber SM, Woodward AR, Palta M. Sleep-disordered breathing and neuropsychological deficits. A population-based study. Am J Respir Crit Care Med. 1997 Dec;156(6):1813-9. doi: 10.1164/ajrccm.156.6.9610026. PMID: 9412560.

Taha BH, Dempsey JA, Weber SM, Badr MS, Skatrud JB, Young TB, Jacques AJ, Seow KC. Automated detection and classification of sleep-disordered breathing from conventional polysomnography data. Sleep. 1997 Nov;20(11):991-1001. doi: 10.1093/sleep/20.11.991. PMID: 9456464.

Young T, Evans L, Finn L, Palta M. Estimation of the clinically diagnosed proportion of sleep apnea syndrome in middle-aged men and women. Sleep. 1997 Sep;20(9):705-6. doi: 10.1093/sleep/20.9.705. PMID: 9406321.

Young T, Peppard P, Palta M, Hla KM, Finn L, Morgan B, Skatrud J. Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med. 1997 Aug 11-25;157(15):1746-52. PMID: 9250236.

Young T, Blustein J, Finn L, Palta M. Sleep-disordered breathing and motor vehicle accidents in a population-based sample of employed adults. Sleep. 1997 Aug;20(8):608-13. doi: 10.1093/sleep/20.8.608. PMID: 9351127.

Young T, Finn L, Kim H. Nasal obstruction as a risk factor for sleep-disordered breathing. The University of Wisconsin Sleep and Respiratory Research Group. J Allergy Clin Immunol. 1997 Feb;99(2):S757-62. doi: 10.1016/s0091-6749(97)70124-6. PMID: 9042068.

1996

Young T, Finn L, Hla KM, Morgan B, Palta M. Snoring as part of a dose-response relationship between sleep-disordered breathing and blood pressure. Sleep. 1996 Dec;19(10 Suppl):S202-5. doi: 10.1093/sleep/19.suppl_10.s202. PMID: 9085511.

Young T, Hutton R, Finn L, Badr S, Palta M. The gender bias in sleep apnea diagnosis. Are women missed because they have different symptoms? Arch Intern Med. 1996 Nov 25;156(21):2445-51. PMID: 8944737.

1994

Wetter DW, Young TB, Bidwell TR, Badr MS, Palta M. Smoking as a risk factor for sleep-disordered breathing. Arch Intern Med. 1994 Oct 10;154(19):2219-24. PMID: 7944843.

Wetter DW, Young TB. The relation between cigarette smoking and sleep disturbance. Prev Med. 1994 May;23(3):328-34. doi: 10.1006/pmed.1994.1046. PMID: 8078854.

Hla KM, Young TB, Bidwell T, Palta M, Skatrud JB, Dempsey J. Sleep apnea and hypertension. A population-based study. Ann Intern Med. 1994 Mar 1;120(5):382-8. doi: 10.7326/0003-4819-120-5-199403010-00005. PMID: 8304655.

1993

Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993 Apr 29;328(17):1230-5. doi: 10.1056/NEJM199304293281704. PMID: 8464434.